Cardiac Autonomic Nervous System in Heart Failure: Imaging Technique and Clinical Implications

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Cardiac Autonomic Nervous System in Heart Failure: Imaging Technique and Clinical Implications

The autonomic nervous system interacts in the pathophysiology of heart failure. Dysfunction of the sympathetic nervous system has been identified as an important prognostic marker in patients with chronic heart failure. At present, cardiac sympathetic nerve imaging with 123-iodine metaiodobenzylguanidine [123-I MIBG] has been employed most frequently for the assessment of cardiac sympathetic in...

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The autonomic nervous system and heart failure.

The pathophysiology of heart failure (HF) is characterized by hemodynamic abnormalities that result in neurohormonal activation and autonomic imbalance with increase in sympathetic activity and withdrawal of vagal activity. Alterations in receptor activation from this autonomic imbalance may have profound effects on cardiac function and structure. Inhibition of the sympathetic drive to the hear...

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Intrinsic cardiac nervous system in tachycardia induced heart failure.

The purpose of this study was to test the hypothesis that early-stage heart failure differentially affects the intrinsic cardiac nervous system's capacity to regulate cardiac function. After 2 wk of rapid ventricular pacing in nine anesthetized canines, cardiac and right atrial neuronal function were evaluated in situ in response to enhanced cardiac sensory inputs, stimulation of extracardiac a...

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THE INTRINSIC CARDIAC NERVOUS SYSTEM in TACHYCARDIA INDUCED HEART FAILURE

Objective: To test the hypothesis that early stage heart failure differentially affects the intrinsic cardiac nervous system’s capacity to regulate cardiac function. Methods: Following 2 wks of rapid ventricular pacing, in 9 anesthetized canines, cardiac and right atrial neuronal function were evaluated in situ in response to enhanced cardiac sensory inputs, stimulation of extracardiac autonomi...

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The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.

Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers countermeasures aimed to restore cardiac output. These responses are compensatory at first but eventually become part of the disease process itself leading to further worsening cardiac function. Among these responses is the activation of the sympathetic nervous system (SNS) that provides inotropic ...

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ژورنال

عنوان ژورنال: Current Cardiology Reviews

سال: 2011

ISSN: 1573-403X

DOI: 10.2174/157340311795677725